Biosketch of Editors

Photo: Dr. Hascall


Vincent C. Hascall : Dr. Vincent Hascall received a Ph. D. from the Rockefeller University in 1969. His thesis research with his classmate, Dr. Stanley Sajdera, concerned the aggregating properties of the cartilage proteoglycan (now called aggrecan), and introduced the dissociative extraction procedures widely used to extract and purify proteoglycans from tissues and cells. After graduation, Dr. Hascall received a faculty appointment in the Departments of Biochemistry and Oral Biology at the University of Michigan. In 1975, he moved to the National Institute of Dental Research in Bethesda to direct research in the Proteoglycan Section. In 1994, Dr. Hascall received his current staff appointment in the Biomedical Engineering Department of the Lerner Research Institute at the Cleveland Clinic Foundation. His research contributions to connective tissue biology and glycobiology have been recognized by such honors as a Doctor of Medicine, honoris causa, from the University of Lund, Sweden; the Karl Meyer Award for Glycoconjugate Research from the Society for Complex Carbohydrates; and an Associate Editorship for the Journal of Biological Chemistry.
Photo: Dr. Yanagishita


Masaki Yanagishita : Dr. Masaki Yanagishita received an M. D. from the Keio University, School of Medicine in 1973. After graduation, he started his clinical training as a resident in internal medicine in the Toranomon Hospital (Tokyo). His research career began in 1975 when he moved to the National Institute of Child Health and Human Development in Bethesda as a Visiting Fellow, where he met with Dr. Vincent Hascall and was fascinated by proteoglycan research. After a short return to the Toranomon Hospital to complete his clinical training in Endocrinology between 1979 and 1980, he moved back to Bethesda to join Dr. Hascall's lab and studied metabolism of proteoglycans especially on heparan sulfate proteoglycans. In 1996, he was appointed to the current position, Professor of the Department of Biochemistry, Tokyo Medical and Dental University, School of Dentistry.
Photo: Dr. Yanagishita


Bryan P. Toole : Bryan Toole was educated in Melbourne, Australia, where he received a B.Sc. degree from the University of Melbourne and a Ph.D. in Biochemistry at Monash University. His Ph.D. work in the laboratory of Professor Dennis Lowther included the initial isolation and purification of the dermatan sulfate proteoglycan, now named decorin, and the first demonstration that decorin interacts with collagen under physiological conditions. In 1968, he moved to Boston for postdoctoral studies at Massachusetts General Hospital and Harvard Medical School in the laboratory of Dr. Jerome Gross. There Dr. Toole showed that hyaluronan surrounds and interacts with motile and proliferating cells during regeneration and embryonic development. In 1972, he joined the Harvard University faculty and established his own laboratory dedicated to the study of hyaluronan-cell interactions in embryonic development and cancer and to the biochemical characterization of hyaluronan receptors. In 1980, he joined the Tufts University Health Sciences Campus in Boston as Professor of Anatomy and Cellular Biology and from 1985 to 1992 was Chair of this Department. He is now the George Bates Professor of Histology and Director of the Ph.D. Program in Cell, Molecular and Developmental Biology at the Tufts Health Sciences Campus. His laboratory continues to focus on hyaluronan-cell interactions in morphogenesis and cancer, as well as on the role of tumor-stromal cell interactions in the regulation of matrix metalloproteinases during metastasis.

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