Table 1 Major vertebrate central nervous tissue
proteoglycans whose cDNA has been cloned.

PGMajor GAGTissueEMBL/Genbank
(source)

Secreted PG
AggrecanCS/KSbrain, cartilageJ03485 (rat)
VersicanCSbrain, mesenchymeX15998 (human)
NeurocanCSbrainM97161 (rat)
Brevican*CSbrainX87096 (mouse)
DecorinCS/DSbrain, connective tissueX59859 (rat)
BiglycanCS/DSbrain, connective tissueU17834 (rat)
TesticanCS/HSbrain, testisX92864 (mouse)
PerlecanHSbrain, basement membraneL22078 (human)
DystroglycanHSbrain, muscleX86073 (mouse)
AgrinHSbrain, muscleM97371 (chick)
ClaustrinKSbrainX67778 (chick)
Transmembrane PG
NG2-PGCSbrain, cartilageX56541 (rat)
RPTPâ─/â└**CS/KSbrain, cartilageU04998 (rat)
Neuroglycan CCSbrainU39553 (rat)
AppicanCSbrain, connective tissueY00264 (human)
N-syndecanHSbrainU73184 (rat)
SV2KSbrainL05435 (rat)
GPI-anchored PG
GlypicanHSbrain, muscleL02896 (rat)
K-glypicanHSbrain, kidneyX83577 (mouse)
CerebroglycanHSbrainL20468 (rat)

PG, proteoglycan; GAG, glycosaminoglycan; CS, chondroitin sulfate;
KS, keratan sulfate; DS, dermatan sulfate; HS, heparan sulfate.
* A portion is linked to the plasma membrane through GPI.
** A soluble splicing variant of RPTPâ─/â└ is called "phosphacan".



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