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Last Updated 2006/12/11 |
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Recent studies on the extracellular matrix
have revealed not only its static function to merely
support cells but also its dynamic function to regulate
cell behaviors by storing and distributing signaling
molecules and growth factors. Thus, importance of the
matrix as microenvironment for the cell has been recognized
by various research fields including development, cancer,
and tissue engineering. On the other hand, recent advances
in carbohydrate researches have demonstrated specific
function of carbohydrates.
The aim of this international symposium, entitled "Extracellular
Glycomatrix", is to connect both fields toward
further understanding of the structure and function
of the extracellular matrix, especially focusing on
carbohydrate molecules such as hyaluronan and proteogylcans. |
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| June 15 (Thu) - 17 (Sat), 2006 |
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|  The
Hyogo Prefectural Awaji Yumebutai International Conference
Center
1 Yumebutai, Awaji Island, Hyogo 656-2306 Japan
TEL:81-799-74-1020
FAX:81-799-74-1021
E-mail: otoiawase@yumebutai.co.jp
URL: http://www.yumebutai.org/conf_e/index.html |
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"Extracellular Glycomatrix in Health and
Disease" Organizing Committee
Chair Person of the Organizing Committee: Koji Kimata
(Institute for Molecular Science of Medicine, Aichi
Medical University) |
|
| Organizing
Committee |
| Chairman:
|
Koji
Kimata (Institute for Molecular Science
of Medicine, Aichi Medical University) |
| Members:
|
Hisashi
Iwata(Nagoya Kyouritsu Hospital)
Masahiko Endo(Hirosaki University
)
Nobuo Kato(Aichi Medical University)
Hidehiko Saito(National Hospital
Organization Nagoya Medical Center)
Masayuki Miyasaka(Osaka University)
Takashi Muramatsu(Aichi Gakuin
University)
Masaki Yanagishita (Tokyo Medical
and Dental University) |
|
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| Scientific
Committee |
| Chairman:
|
Masaki
Yanagishita (Tokyo Medical and Dental
University)
Vincent C. Hascall (The Cleveland
Clinic Foundation) |
| Standing
board members: |
Naoki
Itano (Shinshu University)
Tamayuki Shinomura (Tokyo Medical
and Dental University)
Kazuyuki Sugahara(Kobe Pharmaceutical
University)
Osami Habuchi(Aichi University
of Education)
Masahiko Yoneda (Aichi Prefectural
College of Nursing & Health)
Hideto Watanabe (Institute
for Molecular Science of Medicine, Aichi Medical
University) |
| Members: |
Masayuki Ishihara
(National Defense Medical College )
Atsuhiko
Oohira ( Aichi Human Service Center)
Minoru Okayama (Kyoto Sangyo
University)
Haruko Ogawa
(Ochanomizu University)
Kayoko Oguri
(Nagoya National Hospital)
Reiji Kannagi
(Aichi Cancer Center)
Keiichi Takagaki(Hirosaki
University )
Toshihiko Toida
(Chiba University)
Teruo Nishida
(Yamaguchi University)
Eri Hirasawa
(Juntendo University)
Nobuaki Maeda
(Tokyo Metropolitan Institute for Neuroscience) |
|
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| Advisory
Board |
| |
Torvard
Laurent (Uppsala University)
Ulf Lindahl (Uppsala University)
Dick Heinegard (Lund University)
Bryan Toole (Tufts University)
Tim Hardingham (University
of Manchester)
Jeffrey Esko (University of
California)
Yoshihiko Yamada (NIH)
Guido David (Katholieke Universiteit
Leuven)
Alan Rapraeger (University
of Wisconsin) |
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| Date:
June 15(Thu), 2006 |
Session
1 “Biosynthesis, Structure, and Degradation-1”
Chairperson
Vincent C. Hascall (Lerner Research institute,
Cleveland Clinic Foundation) |
| 09:00-09:25
|
 Vincent
C. Hascall
Special Lecture : "Inter-alpha-Trypsin-Inhibitor
and Hyaluronan: Partners that SHAPe Inflammation" |
| 09:25-09:50 |
Bruce
Caterson
(Connective Tissue Biology Research Group, Cardiff
School of Biosciences, Cardiff University)
“Chondroitin Sulphate sulphation
motifs as potential biomarkers for isolation
of Stem/Progenitor Cells” |
| 09:50-10:15 |
Hisashi
Narimatsu
(National Institute of Advanced Industrial Science
and Technology)
"CS synthases
as members of  3GT
and 4GT
glycosyltransferases" |
| 10:15-10:40 |
Osami
Habuchi
(Department of Chemistry, Aichi University of
Education)
"Functional roles
of N-linked oligosaccharides attached to sulfotransferases
involved in the formation of divergent structures
of chondroitin sulfate" |
| 10:40-11:00 |
COFFEE BREAK |
| 11:00-11:25 |
Paul
H. Weigel
(Department of Biochemistry & Molecular Biology,
University of Oklahoma Health Sciences Center)
"HARE/Stab-2 binds and mediates the
uptake and degradation of multiple glycosaminoglycans" |
| 11:25-11:50 |
John
E. Scott
(Chemical Morphology, Medical School, Manchester
University)
"Our elastic shape
is held together by carbohydrate strings. Implications
for the aetiology of osteoarthrosis" |
| 11:50-13:00 |
POSTER SESSION / LUNCH |
Session
2 “Biosynthesis, Structure, and Degradation-2”
Chairperson
Ulf Lindahl (Department of Medical Biochemistry
and Microbiology, Biomedical Center, Uppsala University)
Masaki Yanagishita (Division of Bio-Matrix, Tokyo
Medical and Dental University) |
| 13:00-13:25 |
Ulf
Lindahl
(Department of Medical Biochemistry and Microbiology,
Biomedical Center, Uppsala University)
"Heparan
sulfate - what will work and what will not? " |
| 13:25-13:50 |
Marion
Kusche-Gullberg
(Section of Physiology, Department of Biomedicine,
University of Bergen)
"EXT1 and
EXT2 proteins and heparan sulfate biosynthesis" |
| 13:50-14:15 |
Kazuyuki
Sugahara
(Graduate School of Life Science, Hokkaido University)
"Functions of chondroitin sulphate
/ dermatan sulphate in the brain development:
Critical roles of E and/or iE disaccharide units
recognized by a specific antibody" |
| 14:15-14:45 |
COFFEE BREAK |
| 14:45-15:10 |
Masaki
Yanagishita
(Division of Bio-Matrix, Tokyo Medical and Dental
University)
"Endocytosis and
intracellular degradation of cell surface heparan
sulfate proteoglycans" |
| 15:10-15:35 |
Anders
Malmstrom
(Lunds University, Department of Experimental
Medical Science)
“Identification
of Dermatan Sulfate Epimerases” |
| 15:35-15:55 |
Yoshimitsu
Kakuta
(Department of Bioscience and Biotechnology, Faculty
of Agriculture, Graduate School, Kyushu University)
"Study of capsule synthetic enzyme
of E. coli" |
| 15:55-19:00 |
POSTER SESSION |
Session
3 “Signal Transduction”
Chairperson
Alan C. Rapraeger (Department of Pathology and
Laboratory Medicine, University of Wisconsin-Madison)
Nobuaki Maeda (Department of Molecular Developmental
Biology, Tokyo Metropolitan Institute for Neuroscience) |
| 19:00-19:25 |
Alan
C. Rapraeger
(Department of Pathology and Laboratory Medicine,
University of Wisconsin-Madison)
“Regulation
of alphaVbeta3 and alphaVbeta5 integrins by syndecan-1
in tumor cell adhesion and angiogenesis” |
| 19:25-19:50 |
Guido
David
(Department of Human Genetics, University of Leuven
and Flanders Interuniversity Institute for Biotechnology)
"Syndecan-assisted endocytic trafficking" |
| 19:50-20:15 |
John
R. Couchman
(Division of Biomedical sciences, Faculty of Medicine,
Imperial College London)
"A ROCK
and role for syndecans in cytoskeletal regulation" |
| 20:15-20:30 |
Nobuaki
Maeda
(Department of Molecular Developmental Biology,
Tokyo Metropolitan Institute for Neuroscience)
"PTPzeta signaling and neural network
formation" |
| 20:30-20:45 |
Eri
Hirasawa
(Juntendo University School of Medicine)
"Role
of perlecan as a modulator in neuromuscular signaling" |
| 20:45-21:00 |
Haruko
Ogawa
(Graduate School of Humanities and Sciences and
The Glycoscience Institute, Ochanomizu University)
"Reactivity and utility of pseudoproteoglycan
probes that simulate proteoglycan supramolecular
structure" |
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| Date:
June 16(Fri), 2006 |
Session 4 “Development,
KO”
Chairperson
Lena Kjellen (Department of Medical Biochemistry
and Microbiology, Uppsala University, BMC)
Yu Yamaguchi (Developmental Neurology, The Burnham
Institute) |
| 08:40-09:05
|
Lena
Kjellen
(Department of Medical Biochemistry and Microbiology,
Uppsala University, BMC)
"Heparan
sulfate biosynthesis: Interaction partners of
the NDST enzymes" |
| 09:05-09:30 |
Yoshihiko Yamada
(Division of Intramural Research, the National
Institute of Dental and Craniofacial Research,
the National Institutes of Health)
"Multiple
functions of perlecan in development and diseases" |
| 09:30-09:55 |
Yu
Yamaguchi
(Developmental Neurology, The Burnham Institute)
"Heparan sulfate as a master regulator
of morphogenetic signaling" |
| 09:55-10:20 |
Scott
B. Selleck
(Department of Pediatrics, Developmental Biology
Center, University of Minnesota )
"Understanding
heparan sulfate proteoglycan function in tissue
assembly using two model systems, the fruitfly
Drosophila and the zebrafish Danio rerio" |
| 10:20-10:40 |
COFFEE BREAK |
| 10:40-11:00 |
Hiroshi
Nakato
(Department of Genetics, Cell Biology and Development,
The University of Minnesota )
"Molecular
mechanisms of Glypican co-receptor function: The
role of drosophila dally in Dpp signaling" |
| 11:00-11:25 |
Takashi
Muramatsu
(Department of Health Science, Faculty of Psychological
and Physical Sciences, Aichi Gakuin University)
"Midkine is important in neurogenesis
and is recognized both by chondroitin sulfate
proteoglycans and heparan sulfate proteoglycans" |
| 11:25-11:50
|
Atsuhiko
Oohira
(Institute for Developmental Research, Aichi Human
Service Center)
"Multiple biological
activities of neuroglycan C, a central nervous
system-specific chondroitin sulfate proteoglycan" |
Session 5 “Special
Lecture”
Chairperson
Minoru Okayama (Faculty of Engineering, Kyoto
Sangyo University) |
| 11:50-12:30 |
Koji
Kimata
(Institute for Molecular Science of Medicine,
Aichi Medical University)
"From
proteoglycans to the enzymes" |
| 12:30-13:30 |
LUNCH |
| 13:30-18:00 |
EXCURSION (Naruto Uzusio [whirling
waves] Cruising) |
| 19:00-21:00 |
BANQUET (The Westin Awaji
Banquet Hall Stella) |
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| Date:
June 17(Sat), 2006 |
Session 6 “Hyaluronan
and Cell Interaction”
Chairperson
Bryan P. Toole (Department of Cell Biology
and Anatomy, Medical University of South Carolina)
Naoki Itano (Institute on Aging and Adaptation,
Graduate School of Medicine, Shinshu University) |
| 09:00-09:25
|
Bryan P. Toole
(Department of Cell Biology and Anatomy, Medical
University of South Carolina)
"Hyaluronan:
An essential partner in oncogenic pathways and
multidrug resistance" |
| 09:25-09:50 |
Warren
Knudson
(The Department of Anatomy and Cell Biology, East
Carolina University)
"Regulation
of CD44 hyaluronan receptor function by protein
acylation" |
| 09:50-10:15 |
Anthony
J. Day
(Faculty of Life Sciences, University of Manchester)
"Hyaluronan-protein interactions
in inflammatory processes" |
| 10:15-10:35 |
COFFEE BREAK |
| 10:35-10:50 |
Kazuki
Sugahara
(Burnham Institute for Medical Research)
"Hyaluronan-CD44
interactions and tumor progression" |
| 10:50-11:05 |
Toshihiko
Toida
(Faculty of Pharmaceutical Sciences, Chiba University)
"Metabolic fate of orally administered
hyaluronan" |
| 11:05-11:20 |
Naoki
Itano
(Institute on Aging and Adaptation, Graduate School
of Medicine, Shinshu University)
"The
role of hyaluronan in tumor angiogenesis." |
| 11:20-11:35 |
Ikuko
Kakizaki
(Hirosaki University School of Medicine)
"Applied
research on inhibitor of hyaluronan synthesis
" |
| 11:35-12:35 |
LUNCH |
Session 7 “Matrix
Formation and Diseases”
Chairperson
James H. Kimura (Development of Surgery,
John A. Burns School of Medicine, University of
Hawaii at Manoa) |
| 12:35-13:00 |
Dick
K. Heinegård
(Department of Cell and Molecular Biology, Lund
University)
"Posttranslational
modifications of extracellular matrix molecules
add functional properties" |
| 13:00-13:25 |
Timothy
E. Hardingham
(UK Centre for Tissue Engineering at The Wellcome
Trust Centre for Cell-Matrix Research, Faculty
of Life Science, University of Manchester)
"Making matrix: Early signals in
chondrogenesis of human adult stem cells" |
| 13:25-13:50 |
James
Kimura
(Development of Surgery, John A. Burns School
of Medicine, University of Hawaii at Manoa)
"Alterations in Extracellular Matrix
Gene Expression During Chondrocyte Dedifferentiation
Detected with DNA Gene Expression Arrays" |
| 13:50-14:10 |
Hideto
Watanabe
(Institute for Molecular Science of Medicine,
Aichi Medical University)
"In
vivo function of versican/PG-M: analysis of knockin
mice" |
| 14:10-14:25 |
COFFEE BREAK |
| 14:25-14:50 |
Thomas
N. Wight
(Benaroya Research Institute at Virginia Mason)
"Hyaluronan and versican (PGM): Partners
in crime in vascular disease" |
| 14:50-15:15 |
Roberto
Perris
(Department of Evolutionary and Functional Biology,
University of Parma)
"NG2 proteoglycan
acts as a master regulator of tumour progression" |
| 15:15-15:40 |
Kayoko
Oguri
(Clinical Research Center, National Hospital Organization
Nagoya Medical Center)
"Functional
analysis of cell surface heparan sulfate proteoglycans
as modulators of MMPs" |
| 15:40-16:00 |
Prachya
Kongtawelert
(Department of Biochemistry, Faculty of Medicine,
Chiang Mai University)
"WF6:
a CS monoclonal antibody and its application in
monitoring joint pathology in vitro and in vivo" |
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