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Sakaru Suzuki$B!JNkLZ!!2"!K(B: $BCx | ||||
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| Fig. 1 $B%R%"%k%m%J%s:?$N(B2$BE|7+$jJV$79=B$$H!"%j%"!<%GlcA$B!K;D4p$N(B2-$B!"(B3-$B0L$H(BN-$B%"%;%A%k%0%k%3%5%_%s!J(BGlcNAc$B!K;D4p$N(B4-$B0L$K$"$k?e;@4p$O>JN,$7$?!#(B | ||||
| Fig.2$B$K$O3F a $B!H%3%s%I%m%$%A%J!<%<(BABC$B!I$H$$$&>&IJL>$GCN$i$l$k9ZAGI8IJ$,<($93h@-$O!"%(%s%I%j%"!<%<$H%(%-%=%j%"!<%<$N6&F1:n6H$K$h$k$b$N$G$"$k!#(B6$B!!(B$B$3$N%(%s%I%j%"!<%<$O!H%3%s%I%m%$%A%J!<%<(BABC$B!"%W%m%F%"!<%<%U%j!&IJL>$G;THN$5$l$F$$$k!#(B |
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| Fig. 2 $B5/86$N0[$J$k%R%"%k%m%J%s%j%"!<%<$H%3%s%I%m%$%A%J!<%<$N4p |
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| Fig. 3 $BFp9|Fy e$N7+$jJV$7(B2$BE|C10L!"(BGlcA-GalNAc4S$B!J(BDi-4S$B$HN,!K$H(BGlcA-GalNAc$B!J(BDi-0S$B$HN,!K$NJ,I[$H(Bgroup B Streptococcus$B%R%"%k%m%J%s%j%"!<%<$K$h$kJ,2r!#(Bm, n, p$B$O!"(BDi4S$BO"B39=B$$N(B2$BE|7+$jJV$7?t!#(BU, G, X, S$B$O!":?$N4T85C$l%0%k%/%m%s;@!"%,%i%/%H!<%9!"%-%7%m!<%9!"%;%j%s$r<($9!J(BBaker$B$i$NO@J8#7$K$J$i$C$F:n@.!K(B |
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$B%R%"%k%m%J%s%j%"!<%<0dEA;R$N%/%m!<%K%s%0$H9ZAG$N:nMQ5!9=(B $B$3$l$^$G$K!"(BStreptococcus agalactiae$B!"(Btype 23 Streptococcus pneumoniae$B!"(BStaphylococcus aureus$B!"(BPropionibacterium$B!!(Bacnes$B$=$l$>$l$KB0$9$k6] $BLLGr$$$N$O!">e5-$N(BS. pneumoniae$BIT40A40dEA;R$,H/8=$9$k(B89kDa$BCGJR!J3+;OE@$,@5>o$G$J$$2 |
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| Fig. 4 $B%R%"%k%m%J%s%j%"!<%Enz$B!K$H4pe$N3h@-1v4p!J(BHis$B!K$O!"4pGlcA$B!K$r%+%k%Y%s;@7?8_JQ0[@-Cf4VBN!J(BC5$B$KITBPEE;R(B2$B8D(B |
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| $B$3$l$^$G$K!"(BStaphylococcus aureus 1801$B$N%R%"%k%m%J%s%j%"!<%<$H!"(BArthrobacter aurescens$B!"(BFlabvobacterium heparinum$B!"(BProteus vulgaris$B$=$l$>$l$N%3%s%I%m%$%A%sN2;@%j%"!<%=2=$5$l$F$$$k!#$=$N$&$A(BF. heparinum$B$N%3%s%I%m%$%A%J!<%<(BAC10$B$H%3%s%I%m%$%A%J!<%<(BB11$B$N7k>=2r@O$,Js9p$5$l$F$$$k!#$=$N7k2L$K$h$l$P!"%3%s%I%m%$%A%J!<%<(BAC$BJ,;R$O(B2$B$D$N%I%a%$%s$+$i@.$j!"(BN-$BKvCFig.5$B!J(BM. Cygler$BGn;N$+$i7CM?!K$K$3$N9ZAGJ,;R$N307A$r<($9!#(BN-$BKvCFig.5A$B!K!#$^$?!"$3$N9B$K$O9b$$J] |
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| Fig. 5 $B%3%s%I%m%$%A%J!<%<(BAC$B$NJ,;RI=LL!#GOD}7AJ,;R$N9B!J(Bcleft$B!K$N>e$K$"$k(BN-$BKvC<&A(B-$B%X%j%+%k%I%a%$%sB&$+$i8+$??^!#8~$+$C$F1&B&$,&A(B-$B%X%j%+%k%I%a%$%s!":8B&$O&B(B-$B%7!<%H%I%a%$%s!#!J(Ba$B!KJ,;RI=LL$N@EEE%]%F%s%7%c%kJ,I[!J(BGRASP10$B;HMQ!K!#@V?'$O1"@-EE2Y!#@D?'$OM[@-EE2Y!#9B!J(Bcleft$B!K$NFbB&I=LL$OA4BNE*$KM[@-$G$"$k$,!"6K$a$F6/$$1"@-NN0h$,>/$7B8:_$9$k!#!J(Bb$B!KJ],Montr |
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Fig.6 $B:Y6]$N"$%0%k%/%m%K%@!<%<$,?(G^$9$k(BN-$B%"%;%A%k%0%k%3%5%_%s$H&A(B-$B%1%H;@@8@.H?1~!#(B |
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| Fig. 7 $B%0%i%`1"@-6]I=LL$N35N,?^!#6]$NI=LL$O(B2$B=EKl9=B$$+$i$J$j!"FbKl$H30Kl$N4V$K$O:YK&JI%Z%W%A%I%0%j%+%s$r4^$`%Z%j%W%i%9%`AX$,$"$k!#30Kl$NI=LL$O%j%]B?F,$Nh2Kl$G$*$*$o$l!"%`%3%$%I3t$G$O$5$i$K%R%"%k%m%J%sh2Kl$,$=$N30B&$r$*$*$&!#h2Kl$+$i%Z%j%W%i%9%`$K$^$?$,$C$F%0%j%3%5%_%N%0%j%+%s%H%i%s%9%]!<%?!GAG transporter$B!K$,J,I[$7!"%0%j%3%5%_%N%0%j%+%s%j%"!<%<72!J(BLYS$B!K$O!"%Z%j%W%i%9%`Fb$KJ,I[$9$k!#$3$l$i%j%"!<%<$K$h$C$F:n$i$l$k@8@.J*$r$5$i$KJ,2r$9$k%9%k%U%!%?!<%<72!J(BS$B!K$d%0%j%3%7%@!<%<72!J(BG$B!K$O:YK&%k$KB8:_$9$k!#(B | ||||
| $B?/=1@-46@w$d=E$$IB5$!JNc$($P5^@-%j%&%^%AG.!K$r$R$-$*$3$9:Y6]%`%3%$%I3t!JNc$($P(Bgroup A streptococci$B!K$NB?$/$,!"%R%"%k%m%J%s$KIY$`h2Kl$G$*$*$o$l$F$$$k$3$H$+$i!"$=$N$h$&$J%R%"%k%m%J%s$O=I b $B%i%C%H>.D2$N%^%9%H:YK&!J$=$NB>$NLH1V:YK&$N0lIt$b!K$K$O?@7P:YK&$,@\6a$7$FB8:_$7!"?@7P%Z%W%A%I!J%K%e!<%m%F%s%7%s$J$I!K$N:nMQ!"5UEAF3@-?@7P;I7c!"%9%H%l%9%1!<%8$X$NM)JD$J$I$K$h$C$F%^%9%H:YK&$N3h@-2=$,$*$3$k!#(B15 |
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| References | ||||
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| 2. | Ohya T, Kaneko Y. Novel hyaluronidase from Streptomyces. Biochim. Biophys. Acta 198: 607-609, 1970. | |||
| 3. | Tam Y-C, Chan EC. Purification and characterization of hyaluronidase from oral Peptostreptococcus species. Infect. Immun. 47: 508-513, 1985. | |||
| 4. | Hiyama K, Okada S. Crystallization and some properties of chondroitinase from Arthrobacter aurescens. J. Biol. Chem. 250: 1824-1828, 1975. | |||
| 5. | Yamagata T, Saito H, Habuchi O, Suzuki S. Purification and properties of bacterial chondroitinases and chondrosulfatases. J. Biol. Chem. 243: 1523-1535, 1968. | |||
| 6. | Hamai A, Hashimoto N, Mochizuki H, Kato F, Makiguchi Y, Horie K, Suzuki S. Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides. J. Biol. Chem. 272: 9123-9130, 1997. | |||
| 7. | Baker JR, Yu H, Morrison K, Averett WF, Pritchard DG. Specificity of the hyaluronate lyase of group B Streptococcus toward unsulphated regions of chondroitin sulphate. Biochem. J. 327(Pt1): 65-71, 1997. | |||
| 8. | Gase K, Ozegowski J, Malke H. The Streptococcus agalactiae hylB gene encoding hyaluronate lyase. Completion of the sequence and expression analysis. Biochim. Biophys. Acta 1398: 86-98, 1998. | |||
| 9. | Greiling H, Stuhlsatz HW, Eberhard T, Eberhard A. Studies on the mechanism of hyaluronan lyase action. Connect. Tissue Res. 3: 135-139, 1975. | |||
| 10. | F |
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| 11. | Huang W, Matte A, Li Y, Kim YS, Linhardt RJ, Su H, Cygler M, Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 resolution. J. Mol. Biol. 294: 1257-1269, 1999. | |||
| 12. | Linker A, Hoffman P, Meyer K, Sampson P, Korn ED. The formation of unsaturated disaccharides from mucopolysaccharides and their cleavage to alpha-keto acid by bacterial enzyme. J. Biol. Chem. 235: 3061-3065, 1960. | |||
| 13. | Cheng Q, Yu MC, Reeves AR, Salyers AA. Identification and characterization of a Bacteroides gene, csuF, which encodes an outer membrane protein that is essential for growth on chondroitin sulfate. J. Bacteriol. 177: 3721-3727, 1995. | |||
| 14. | Levin JC, Wessels MR. Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A Streptococcus. Mol. Microbiol. 30: 209-219, 1998. | |||
| 15. | Theoharides TC, Letourneau R, Patra P, Hesse L, Pang X, Boucher W, Mompoint C, Harrington B. Stress-induced rat intestinal mast cell intragranular activation and inhibitory effect of sulfated proteoglycans. Digest. Dis. Sci. 44(8 Suppl): 87S-93S, 1999. | |||
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