Hyaluronan Image Symbol
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 Authors' Profile
Sakaru Suzuki$B!JNkLZ!!2"!K(B: $BCx8E20Bg3X$+$iM}3XGn;N9f$r8E20Bg3XM}3XIt2=3X2J65
I $B$^$($,$-(B 1934$BG/$K(BMeyer$B$H(BPalmer$B$,%R%"%k%m%J%s$rH/8+$7$F4V$b$J$/!"(BMeyer$B$N8&5f%0%k!<%W$O!"(B2$B7?GY1jAP5e6]!J(Btype 2 pneumococcus$B!"JLL>!'(BStreptococcus pneumoniae$B!K$NCj=P1U$K%R%"%k%m%J%s$rDcJ,;R2=$9$k9ZAG3h@-$,$"$k$3$H$rL@$+$K$7$?!#$=$N8e!"B?$/$N8&5fClostridium$B!J%/%m%9%H%j%G%$%&%`!K!"(BMicrococcus$B!J%_%/%m%3%C%+%9!K!"(BStreptococcus$B!J%9%H%l%W%H%3%C%+%9!K!"(BPropionibacterium$B!J%W%m%T%*%s;@6]!K!"(BPeptococcus$B!J%Z%W%H%3%C%+%9!K!"(BStrptomyces$B!J%9%H%l%W%H%_%;%9!K$J$I$KB0$9$k$$$m$$$m$J6]I$N0x;R$r2rL@$9$k$N$K!"%R%"%k%m%J%sJ,2r9ZAG$N8&5f$OHr$1$FDL$l$J$$$H$$$&>u67$,$"$k$?$a$G$"$k!#$3$l$i$N9ZAG$K$O$b$&$R$H$DJL$N4i$,$"$k!#$=$l$O!"$9$G$K$3$N%7%j!<%:$G>R2p$5$l$F$-$?$h$&$K!"I!"AO=}<#L~!"$,$sE>0\$G$N%R%"%k%m%J%s$NLr3d$r8&5f$9$kM-8z$J;nLt$H$7$F$N4i$G$"$k!#(B
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II $B@8@.J*$NJ,@O$H9ZAG$NFC0[@-(B $B:Y6]$*$h$S%9%H%l%W%H%_%;%9!JJ|@~6]!K$+$iJ,N%$5$l$?%R%"%k%m%J%s%j%"!<%$N@8J*D-$B%0%k%3%5%_%s$H(BD-$B%0%k%/%m%s;@$r7k$V&B(B-1,4$B%0%j%3%7%I7k9g$r@ZCG$9$k$,!"8eFig.1)$B!#$=$N7k2L!"A01$B!!(B$B$3$l$iC1E|!"(B2$BE|$NJ,N%$K$O(BHPLC$B$d%]%j%"%/%j%k%"%_%I%2%kEE5$1KF0$,;H$o$l$F$$$k!#(B
Fig. 1 $B%R%"%k%m%J%s:?$N(B2$BE|7+$jJV$79=B$$H!"%j%"!<%GlcA$B!K;D4p$N(B2-$B!"(B3-$B0L$H(BN-$B%"%;%A%k%0%k%3%5%_%s!J(BGlcNAc$B!K;D4p$N(B4-$B0L$K$"$k?e;@4p$O>JN,$7$?!#(B
Fig.2$B$K$O3FStreptomyces hyalurolyticus$B$+$i@:@=$7$?9ZAG$G%R%"%k%m%J%s0J30$N%0%j%3%5%_%N%0%j%+%s!"Nc$($P%3%s%I%m%$%A%s!"%3%s%I%m%$%A%s(B4 / 6-$BN2;@!"%G%k%^%?%sN2;@!"%1%i%?%sN2;@!"%X%Q%i%sN2;@!"%X%Q%j%s$K$OA4$/:nMQ$7$J$$!#(B2$B!!0lJ}!"(BStreptococcus dysgalactiae$B$H(BPeptococcus$B$+$i@:@=$5$l$?9ZAG$O3$B!!(B$BBh(B3$B$N7?$O(BArthrobacter$B$+$i@:@=$5$l!H%3%s%I%m%$%A%J!<%<(BAC1$B%"%k%9%m!I$H$$$&>&IJL>$G;THN$5$l$F$$$k9ZAG$G$"$k!#$3$N9ZAG$O%R%"%k%m%J%s$r$b$C$H$bB.$/J,2r$9$k0lJ}$G!"%3%s%I%m%$%A%s$H%3%s%I%m%$%A%s(B4 / 6-$BN2;@$r$=$l$>$l(B2/3$B$*$h$S(B1/3$B$NB.EY$GJ,2r$9$k!#(B4 $B!H%3%s%I%m%$%A%J!<%<(BABC$B!I!J(BProteus vulgaris NCTC 4636$B$+$i@:@=!K$H!H%3%s%I%m%$%A%J!<%<(BAC-$B*!%U%i%\!I!J(BFlavobacterium heparinum ATCC 13125$B$+$i@:@=!K$H8F$P$l$F$$$k;THN9ZAG$O!"%R%"%k%m%J%s$K$b:nMQ$9$k$,!"$=$NB.EY$O%3%s%I%m%$%A%s$*$h$S%3%s%I%m%$%A%s(B4/6-$BN2;@$KBP$9$kJ,2rB.EY$h$j$b$O$k$+$KDc$$!#(B5,a$B!!$7$?$,$C$F!"J#?t$N%0%j%3%5%_%N%0%j%+%s$h$j@.$k8!BN$r%j%"!<%<>C2=$K$h$C$FJ,@O$9$k>l9g$K$O!"5/86$N0[$J$k%j%"!<%<$NFC0[@-$N0c$$$K$h$C$F@8$:$k:.Mp$rHr$1$k$?$a!"2?$i$+$NAjJdE*$J5;=Q$rJ;MQ$9$k$3$H$r$9$9$a$?$$!#(B

a $B!H%3%s%I%m%$%A%J!<%<(BABC$B!I$H$$$&>&IJL>$GCN$i$l$k9ZAGI8IJ$,<($93h@-$O!"%(%s%I%j%"!<%<$H%(%-%=%j%"!<%<$N6&F1:n6H$K$h$k$b$N$G$"$k!#(B6$B!!(B$B$3$N%(%s%I%j%"!<%<$O!H%3%s%I%m%$%A%J!<%<(BABC$B!"%W%m%F%"!<%<%U%j!&IJL>$G;THN$5$l$F$$$k!#(B
Fig. 2 $B5/86$N0[$J$k%R%"%k%m%J%s%j%"!<%<$H%3%s%I%m%$%A%J!<%<$N4p$l$NJ,2rB.EY$r%Q!<%;%s%H$G<($9!#$=$l$>$l$NH?1~(BpH$B$O3g8LFb$K<($5$l$F$$$k!#(BB$B!(%3%s%I%m%$%A%s(B4/6-$BN2;@$NJ,2rB.EY$r(B100$B$H$7$F!"(BA$B$HF1$8$h$&$K%R%"%k%m%J%s$H%3%s%I%m%$%A%s$NJ,2rB.EY$r%Q!<%;%s%H$G<($9!#(B
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III $B:nMQMM<0(B Streptomyces hyalurolyticus$B$N%R%"%k%m%J%s%j%"!<%Streptococcus agalactiae 3502$B$N%R%"%k%m%J%s%j%"!<%<$rHf$Y$F$_$k$H!"A0$l$r!JHs4T85KvC<$+$i!KC`7$B!!(B$B$*$b$7$m$$$3$H$K!"$3$N9ZAG$O%R%"%k%m%J%s$N$_$G$J$/!"$"$kC2=$7$F:n$C$?$b$N!K$K$b$f$C$/$j$H$7$?B.EY$G:nMQ$9$k!#$3$N%3%s%I%m%$%A%sN2;@I8IJ$O!"0lK\$N:?$"$?$jJ?6Q(B5$B8D$N(B2$BE|C10L$,N2;@4p$r7gG!$7$F$*$j!"(BStreptococcus$B$N%R%"%k%m%J%s%j%"!<%<$O!"(BFig.3$B$K<($9$h$&$K%3%"CAGr$H$N7k9gNN0h$K6a@\$7$F>/$J$/$H$b(B2$B$DB8:_$9$kHsN2;@2=#2E|%/%i%9%?!<$NItJ,$rFC$K9%$s$G@Z$k@-
Fig. 3 $BFp9|Fye$N7+$jJV$7(B2$BE|C10L!"(BGlcA-GalNAc4S$B!J(BDi-4S$B$HN,!K$H(BGlcA-GalNAc$B!J(BDi-0S$B$HN,!K$NJ,I[$H(Bgroup B Streptococcus$B%R%"%k%m%J%s%j%"!<%<$K$h$kJ,2r!#(Bm, n, p$B$O!"(BDi4S$BO"B39=B$$N(B2$BE|7+$jJV$7?t!#(BU, G, X, S$B$O!":?$N4T85C$l%0%k%/%m%s;@!"%,%i%/%H!<%9!"%-%7%m!<%9!"%;%j%s$r<($9!J(BBaker$B$i$NO@J8#7$K$J$i$C$F:n@.!K(B
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IV $B%R%"%k%m%J%s%j%"!<%<0dEA;R$N%/%m!<%K%s%0$H9ZAG$N:nMQ5!9=(B $B$3$l$^$G$K!"(BStreptococcus agalactiae$B!"(Btype 23 Streptococcus pneumoniae$B!"(BStaphylococcus aureus$B!"(BPropionibacterium$B!!(Bacnes$B$=$l$>$l$KB0$9$k6]8$B!!$3$l$i$NCf$G$b$C$H$b?7$7$$Js9p$G$O!"(B Streptococcus$B%R%"%k%m%J%s%j%"!<%<0dEA;R!H(BhylB 4755$B!H$N40A4G[Ns$,7h$a$i$l$F$$$k!#$3$N0dEA;R$O!"%"%_%N;@(B30$B$h$j@.$k%7%0%J%kG[Ns$r$b$C$?(B1072$B%"%_%N;@%]%j%Z%W%A%I$r%3!<%I2=$9$k!#(B hylB 4755$B$N0[7AH/8=$O!"$=$l<+?H$,$b$D%W%m%b!<%?!<$K$h$C$F8zN($h$/9T$o$l!"40A4$J9ZAGCAGrJ,;R!J(B118kDa$B!K$,@8@.$9$k!#$3$N9ZAGCAGr$O!"0JA0$K(BS. agalactiae 3502$B3t$H(Btype 23 S. pneumoniae$B$=$l$>$l$+$iF@$i$l$?0dEA;R$,%3!<%I2=$9$k9ZAG$H9b$$%[%b%m%8!<$r<($9$,!"8eFs
$BLLGr$$$N$O!">e5-$N(BS. pneumoniae$BIT40A40dEA;R$,H/8=$9$k(B89kDa$BCGJR!J3+;OE@$,@5>o$G$J$$2S. agalactiae 3502$B3t$+$i%/%m!<%K%s%0$5$l$?IT40A4$J0dEA;R!H(BhylB 3502$B!H$rMQ$$$FF@$i$l$?9ZAG$G$O!"$=$N3h@-$K4XM?$9$k%"%_%N;@;D4p$H$7$F(BHis-567$B$,F1Dj$5$l$F$*$j!"$=$l$KAjEv$9$k(BHis$B;D4p$,(BhylB 4755$BCAGr$K$b4^$^$l$F$$$k$3$H$G$"$k!#$3$l$i$N7k2L$O!"$+$J$j0JA0$KJs9p$5$l$F$$$k2<5-$N4Q;!$H$b$h$/0lCW$7$F$$$k!#(B group A streptococci$B$+$i@:@=$7$?!JE7A3$N!K%R%"%k%m%J%s%j%"!<%<$r%a%A%l%s@DB8:_2<$G8w;@2=$K$+$1$k$H!"%R%9%A%8%s;D4p4^NL$,8:>/$9$k$N$KHfNc$7$F9ZAG3h@-$,Dc2<$9$k!#$5$i$K!"%R%9%A%8%s;D4p$N%$%_%@%>!<%k4D$r%(%-%=967b$9$k%"%k%-%k2=:^(BTPCK$B$H$NH?1~$G$b9ZAG3h@-$,Dc2<$9$k!#(B9$B!!(BFig.4$B$O!"%R%"%k%m%J%s%j%"!<%<$N:nMQ5!9=$H$7$F!"%R%9%A%8%s;D4p$N%$%_%@%>!<%k4D$,%&%m%s;@;D4p$N(BC-5$B$+$i%W%m%H%s$r0z$-$L$/F/$-$r$9$k$H$$$&A[Dj$G2h$$$?$b$N$G$"$k!#$3$N$h$&$J%W%m%H%s0z$-$L$-$N2DG=@-$r$b$D%"%_%N;@;D4p$OB>$K$b$"$k$H;W$&$,!":#$N$H$3$m%R%"%k%m%J%s%j%"!<%@\4XM?$9$k$H$$$&>Z5r$OJs9p$5$l$F$$$J$$!#(B
Fig. 4 $B%R%"%k%m%J%s%j%"!<%Enz$B!K$H4pe$N3h@-1v4p!J(BHis$B!K$O!"4pGlcA$B!K$r%+%k%Y%s;@7?8_JQ0[@-Cf4VBN!J(BC5$B$KITBPEE;R(B2$B8D(B$B$r$b$D!K$KJQ$($k!#$3$NCf4VBN$O%0%k%3%5%_%s;D4p$H$N7k9g$r@Z$k$3$H$K$h$C$F0BDj$J"$ITK0OB9=B$$K0\9T$9$k!#(B
$B$3$l$^$G$K!"(BStaphylococcus aureus 1801$B$N%R%"%k%m%J%s%j%"!<%<$H!"(BArthrobacter aurescens$B!"(BFlabvobacterium heparinum$B!"(BProteus vulgaris$B$=$l$>$l$N%3%s%I%m%$%A%sN2;@%j%"!<%=2=$5$l$F$$$k!#$=$N$&$A(BF. heparinum$B$N%3%s%I%m%$%A%J!<%<(BAC10$B$H%3%s%I%m%$%A%J!<%<(BB11$B$N7k>=2r@O$,Js9p$5$l$F$$$k!#$=$N7k2L$K$h$l$P!"%3%s%I%m%$%A%J!<%<(BAC$BJ,;R$O(B2$B$D$N%I%a%$%s$+$i@.$j!"(BN-$BKvCFig.5$B!J(BM. Cygler$BGn;N$+$i7CM?!K$K$3$N9ZAGJ,;R$N307A$r<($9!#(BN-$BKvCFig.5A$B!K!#$^$?!"$3$N9B$K$O9b$$J]Fig.5B$B!K!#$3$l$O!"%3%s%I%m%$%A%J!<%<(BAC$B!J(BArthrobacter$B!K$H4p10$B!!(B$B%3%s%I%m%$%A%J!<%<(BB$B$N7k>=9=B$$O!"%3%s%I%m%$%A%J!<%<(BAC$B$N$=$l$H$OBP>HE*$K!"%Z%/%A%s;@%j%"!<%<$d%]%j%,%i%/%A%e%m%J%s%R%I%m%i!<%<7?$N@^$j$?$?$_&B(B-$B%X%j%C%/%9%9!<%Q!<%U%!%_%j!<$KB0$9$k!#(B11$B!!:#8e$5$i$K!"%R%"%k%m%J%s%j%"!<%<$d$=$l$i$K4X78$N$"$k9ZAG72$NFMA3JQ0[$d7k>=2r@O$N8&5f$,$9$9$a$P!"B?E|%j%"!<%<72$NM}2r$O$h$j?<$/$J$j!"$=$l$i%j%"!<%<72$N@8J*3XE*5!G=$N8&5f$,0lCJ$HB%?J$5$l$k$3$H$K$J$m$&!#(B

Fig. 5 $B%3%s%I%m%$%A%J!<%<(BAC$B$NJ,;RI=LL!#GOD}7AJ,;R$N9B!J(Bcleft$B!K$N>e$K$"$k(BN-$BKvC<&A(B-$B%X%j%+%k%I%a%$%sB&$+$i8+$??^!#8~$+$C$F1&B&$,&A(B-$B%X%j%+%k%I%a%$%s!":8B&$O&B(B-$B%7!<%H%I%a%$%s!#!J(Ba$B!KJ,;RI=LL$N@EEE%]%F%s%7%c%kJ,I[!J(BGRASP10$B;HMQ!K!#@V?'$O1"@-EE2Y!#@D?'$OM[@-EE2Y!#9B!J(Bcleft$B!K$NFbB&I=LL$OA4BNE*$KM[@-$G$"$k$,!"6K$a$F6/$$1"@-NN0h$,>/$7B8:_$9$k!#!J(Bb$B!KJ],Montral,Qubec,Canada$B!K$N9%0U$K$h$jE>:\!#(B

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V $B@8J*3XE*5!G=(B $B$O$8$a$K$b=R$Y$?$h$&$K!"%R%"%k%m%J%s%j%"!<%<$N:G=*@8@.J*$O!"Streptomyces hyalurolyticus$B%R%"%k%m%J%s%j%"!<%<$ONc30$G!"&$(B4$B!A(B6$BE|$,:G=*@8@.J*$G$"$k!#$3$l$i&$(B2$BE|;:@8Hy@8J*$NB?$/$O!"$=$N(B2$BE|$+$i&A(B-$B%1%H;@$H(BN-$B%"%;%A%k%0%k%3%5%_%s$r@8@.$9$k&B(B-$B%0%k%/%m%K%@!<%<$r$b$C$F$$$k!J(BFig.6$B!K!#(B12

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$B$7$?$,$C$F!"$3$l$i$N:Y6]!"$H$j$o$1%R%H7kD2$NHy@8J*AQ$KB8:_$9$k:Y6]$K$H$C$F=IBacteroides thetaiotaomicron 5482$B$O$=$N$h$&$J7kD2@8B):Y6]$N0l$D$G$"$k$,!"$=$NLn@83t$+$i!"%H%i%s%9%]%>%sA^F~$K$h$C$FF@$i$l$?JQ0[3t!H(BCS4$B!I$O!"%R%"%k%m%J%s$d%3%s%I%m%$%A%sN2;@$r1IM\8;$H$7$F@8D9$9$k$3$H$,$G$-$J$$$K$b$+$+$o$i$:!"A0$b$C$F$=$l$iB?E|$r%j%"!<%<$GJ,2r$7$FF@$i$l$k&$(B2$BE|$rMxMQ$7$F@8D9$9$kG=NO$r$b$C$F$$$k!#(B13$B!!(B$B$3$N(BCS4$BJQ0[$O!":Y6]:YK&$N30It:YK&Kl$KB8:_$9$kHs9ZAGCAGr$r%3!<%I2=$9$kC10l0dEA;R!H(BCSUF$B!I$NJQ0[$K$h$C$FF3$+$l$?$b$N$G$"$k!#$3$N7k2L$+$i$_$F!"%R%"%k%m%J%s$d%3%s%I%m%$%A%sN2;@$O!"$^$:0lFig.7$B!K!#(B

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